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VVD-442

CAT: 0804-HY-176811Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176811Size:1 Each
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Description
VVD-442 is a covalent RAS-PI3K inhibitor. VVD-442 binds covalently to cysteine 242 in the RAS binding domain of PI3K p110α and blocks RAS/PI3K interaction. VVD-442 can be used cancers like breast cancer research[1].
CAS Number
3055318-88-9
UNSPSC
12352005
Target
PI3K; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
BrC1=CC(C2=C(Cl)C=CC=C2)=C(S(N3CCC(C(N[C@H](C)/C=C\S(C)(=O)=O)=O)(F)CC3)(=O)=O)C=C1
Molecular Formula
C23H25BrClFN2O5S2
Molecular Weight
607.94
References & Citations
[1]Klebba JE, et al. Covalent inhibitors of the RAS binding domain of PI3Kα impair tumor growth driven by RAS and HER2. bioRxiv [Preprint]. 2024 Dec 20:2024.12.17.629001.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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