VVD-442

• Description :

  VVD-442 is a covalent RAS-PI3K inhibitor. VVD-442 binds covalently to cysteine 242 in the RAS binding domain of PI3K p110α and blocks RAS/PI3K interaction. VVD-442 can be used cancers like breast cancer research[1].

• UNSPSC :

  12352005

• Target :

  PI3K; Ras

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR

• Field of Research :

  Cancer

• Smiles :

  BrC1=CC(C2=C(Cl)C=CC=C2)=C(S(N3CCC(C(N[C@H](C)/C=C\S(C)(=O)=O)=O)(F)CC3)(=O)=O)C=C1

• Molecular Formula :

  C23H25BrClFN2O5S2

• Molecular Weight :

  607.94

• References & Citations :

  [1]Klebba JE, et al. Covalent inhibitors of the RAS binding domain of PI3Kα impair tumor growth driven by RAS and HER2. bioRxiv [Preprint]. 2024 Dec 20:2024.12.17.629001.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3055318-88-9]