VVD-699

• Target :

  PI3K|||Ras

• Related Pathways :

  PI3K/Akt/mTOR signaling|||MAPK|||GPCR/G Protein

• Bioactivity :

  VVD-699 is a covalent inhibitor of RAS-PI3K. It forms a covalent bond with cysteine at position 242 within the RAS-binding domain of PI3Kp110?, thereby obstructing the ability of RAS to activate PI3K. VVD-699 is capable of inhibiting the growth of tumors with RAS mutations and HER2 overexpression. It is applicable in research related to RAS mutation-associated cancers, such as those involving H358 lung cancer cells, A549 cells, and FaDu cells.

• Smiles :

  S(=O)(=O)(C1=C(C=C(OC)C=C1)C2=C(Cl)C=CC=C2)N3[C@H](C)C[C@@](C(N[C@@H](/C=C\S(C)(=O)=O)C)=O)(F)CC3

• Molecular Formula :

  C25H30ClFN2O6S2

• Molecular Weight :

  573.097

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3055319-82-6