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VVD-699

CAT: 0931-T206721-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206721-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3055319-82-6
Target
PI3K, Ras
Related Pathways
PI3K/Akt/mTOR signaling, MAPK, GPCR/G Protein
Bioactivity
VVD-699 is a covalent inhibitor of RAS-PI3K. It forms a covalent bond with cysteine at position 242 within the RAS-binding domain of PI3Kp110α, thereby obstructing the ability of RAS to activate PI3K. VVD-699 is capable of inhibiting the growth of tumors with RAS mutations and HER2 overexpression. It is applicable in research related to RAS mutation-associated cancers, such as those involving H358 lung cancer cells, A549 cells, and FaDu cells.
Smiles
S(=O)(=O)(C1=C(C=C(OC)C=C1)C2=C(Cl)C=CC=C2)N3[C@H](C)C[C@@](C(N[C@@H](/C=C\S(C)(=O)=O)C)=O)(F)CC3
Molecular Formula
C25H30ClFN2O6S2
Molecular Weight
573.097
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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