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HDAC6-IN-61

CAT: 0804-HY-176733Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176733Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC6-IN-61 (Compound 4e) is a HDAC6 inhibitor (IC50: 73 nM) with selectivity over other HDAC isoforms. HDAC6-IN-61 is also a GPR40 activator. HDAC6-IN-61 increases acetylated tubulin and ERK phosphorylation levels. HDAC6-IN-61 can be used for research of neuroinflammation such as Alzheimer's disease[1].
UNSPSC
12352211
Target
ERK; Free Fatty Acid Receptor; HDAC; Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Neurological Disease
Smiles
O=C(NO)CCC1=CC=C(C=C1)NCC2=CC3=C(S2)C=CC=C3
Molecular Formula
C18H18N2O2S
Molecular Weight
326.41
References & Citations
[1]Pinheiro PSM, et al. Design, synthesis and pharmacological evaluation of multitarget GPR40 agonists/HDAC6 inhibitors for Alzheimer's disease. Eur J Med Chem. 2025 Jun 13;296:117868.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC5; HDAC6; HDAC8

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