ONO-TR-772

CAT: 0804-HY-176411-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-176411-01Size:5 mg
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Description
ONO-TR-772 (VU6018042) is a selective TREK inhibitor (IC50: 15 nM) . ONO-TR-772 enhances recognition memory in the MK-801-stimulated NOR mouse model. ONO-TR-772 can be used in the study of diseases related to cognitive impairment[1].
CAS Number
[2640847-32-9]
Product Name Alternative
VU6018042
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Purity
99.43
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=CC(C#CC2=CC=C(F)C=C2)=CN=C1NC(C3=C(Cl)C=CC(NC(OC(C)(C)C)=O)=C3)=O
Molecular Formula
C26H23ClFN3O3
Molecular Weight
479.93
References & Citations
[1]Tanaka M, et al. Discovery of ONO-TR-772 (VU6018042) : A Highly Selective and CNS Penetrant TREK Inhibitor in Vivo Tool Compound. ACS Med Chem Lett. 2025 Apr 28;16 (5) :896-901.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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