ONO-TR-772

• Description :

  ONO-TR-772 (VU6018042) is a selective TREK inhibitor (IC50: 15 nM) . ONO-TR-772 enhances recognition memory in the MK-801-stimulated NOR mouse model. ONO-TR-772 can be used in the study of diseases related to cognitive impairment[1].

• Product Name Alternative :

  VU6018042

• UNSPSC :

  12352005

• Target :

  Potassium Channel

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Neurological Disease

• Purity :

  99.43

• Solubility :

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CC1=CC(C#CC2=CC=C(F)C=C2)=CN=C1NC(C3=C(Cl)C=CC(NC(OC(C)(C)C)=O)=C3)=O

• Molecular Formula :

  C26H23ClFN3O3

• Molecular Weight :

  479.93

• References & Citations :

  [1]Tanaka M, et al. Discovery of ONO-TR-772 (VU6018042) : A Highly Selective and CNS Penetrant TREK Inhibitor in Vivo Tool Compound. ACS Med Chem Lett. 2025 Apr 28;16 (5) :896-901.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2640847-32-9]