EIF4E/eIF4G PPI-IN-1

CAT: 0804-HY-176288Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-176288Size:1 Each
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Description
EIF4E/eIF4G PPI-IN-1 is an eIF4E/eIF4G interaction inhibitor with a KD of 20.2 μM for eIF4E protein. eIF4E/eIF4G PPI-IN-1 plays an antitumor role in multiple modes of action including regulating the activity of eIF4E by inhibiting the Ras/MAPK/eIF4E signaling pathway, apoptosis and cell migration. eIF4E/eIF4G PPI-IN-1 suppresses the growth of HepG2 xenografts in nude mice and was relatively nontoxic to mice[1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Eukaryotic Initiation Factor (eIF) ; PERK; Ras
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
OC1=CC=C(C=C1)C2=CC=C(O2)/C=N/NC3=NC(C4=CC(Cl)=C(C=C4)Cl)=CS3
Molecular Formula
C20H13Cl2N3O2S
Molecular Weight
430.31
References & Citations
[1]Yao B, et al. Discovery of novel hydrazinyl thiazole derivatives as potent anticancer agents by inhibiting eIF4E/eIF4G interactions. Eur J Med Chem. 2025 Jun 26;297:117911.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; eIF4

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