EIF4E/eIF4G PPI-IN-1

• Description:

  EIF4E/eIF4G PPI-IN-1 is an eIF4E/eIF4G interaction inhibitor with a KD of 20.2 μM for eIF4E protein. eIF4E/eIF4G PPI-IN-1 plays an antitumor role in multiple modes of action including regulating the activity of eIF4E by inhibiting the Ras/MAPK/eIF4E signaling pathway, apoptosis and cell migration. eIF4E/eIF4G PPI-IN-1 suppresses the growth of HepG2 xenografts in nude mice and was relatively nontoxic to mice[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Bcl-2 Family; Eukaryotic Initiation Factor (eIF) ; PERK; Ras

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  OC1=CC=C(C=C1)C2=CC=C(O2)/C=N/NC3=NC(C4=CC(Cl)=C(C=C4)Cl)=CS3

• Molecular Formula:

  C20H13Cl2N3O2S

• Molecular Weight:

  430.31

• References & Citations:

  [1]Yao B, et al. Discovery of novel hydrazinyl thiazole derivatives as potent anticancer agents by inhibiting eIF4E/eIF4G interactions. Eur J Med Chem. 2025 Jun 26;297:117911.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Bcl-2; eIF4