EIF4E-IN-5

• Description :

  EIF4E-IN-5 (Compound 6n) is a eIF4E cell-permeable inhibitor. eIF4E-IN-5 can bind to capped mRNA to inhibit cap-dependent translation[1].

• UNSPSC :

  12352005

• Target :

  Eukaryotic Initiation Factor (eIF)

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/eif4e-in-5.html

• Solubility :

  10 mM in DMSO

• Smiles :

  NC1=NC2=C(C(N1)=O)[N+](CC3=CC4=C(N3)C=CC(Cl)=C4)=CN2C/C=C\CP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O.[Cl-]

• Molecular Formula :

  C30H39Cl2N6O8P

• Molecular Weight :

  713.55

• References & Citations :

  [1]Cárdenas EL, et al. Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer. J Med Chem. 2023 Aug 10;66 (15) :10734-10745.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported