EIF4E-IN-4

• Description :

  EIF4E-IN-4 (Compound 33) is a selective inhibitor of eukaryotic initiation factor 4E (eIF4E) with biochemical activity value of 95 nM. eIF4E-IN-4 inhibits cap-dependent mRNA translation with an IC50 value of 2.5 μM. eIF4E-IN-4 can be used for breast cancer, colon cancer, and head and neck cancer study[1].

• UNSPSC :

  12352005

• Target :

  Eukaryotic Initiation Factor (eIF)

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C1N=C(NC)NC2=C1N(CCOC3=CC=C(C=C3)Cl)C(C4=CC=C(P(O)(O)=O)C=C4)=N2

• Molecular Formula :

  C20H19ClN5O5P

• Molecular Weight :

  475.82

• References & Citations :

  [1]Chen X, et al. Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction. J Med Chem. 2012 Apr 26;55 (8) :3837-51.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1373822-39-9]