EIF4E-IN-4

CAT: 0804-HY-148664Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-148664Size:1 Each
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Description
EIF4E-IN-4 (Compound 33) is a selective inhibitor of eukaryotic initiation factor 4E (eIF4E) with biochemical activity value of 95 nM. eIF4E-IN-4 inhibits cap-dependent mRNA translation with an IC50 value of 2.5 μM. eIF4E-IN-4 can be used for breast cancer, colon cancer, and head and neck cancer study[1].
CAS Number
[1373822-39-9]
UNSPSC
12352005
Target
Eukaryotic Initiation Factor (eIF)
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1N=C(NC)NC2=C1N(CCOC3=CC=C(C=C3)Cl)C(C4=CC=C(P(O)(O)=O)C=C4)=N2
Molecular Formula
C20H19ClN5O5P
Molecular Weight
475.82
References & Citations
[1]Chen X, et al. Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction. J Med Chem. 2012 Apr 26;55 (8) :3837-51.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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