EIF4E/eIF4G PPI-IN-1

CAT: 0931-T210985-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T210985-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PERK|||Apoptosis|||Bcl-2 Family|||Ras
Related Pathways
Apoptosis|||MAPK
Bioactivity
EIF4E/eIF4G PPI-IN-1 is an inhibitor that disrupts the interaction between eIF4E and eIF4G, exhibiting a dissociation constant (KD) of 20.2 ?M for the eIF4E protein. It demonstrates antitumor effects through various mechanisms, including modulation of eIF4E activity via inhibition of the Ras/MAPK/eIF4E signaling pathway, influencing apoptosis and cell migration. Additionally, eIF4E/eIF4G PPI-IN-1 inhibits the growth of HepG2 xenografted tumors in nude mice and is relatively non-toxic to mice.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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