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PI3Kα-IN-26

CAT: 0804-HY-176281Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176281Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PI3Kα-IN-26 (Compound 11e) is a PI3Kα inhibitor with an IC50 of 75.31 nM. PI3Kα-IN-26 has a broad-spectrum anticancer activity, such as leukemia, colon and breast cancer, without significant cytotoxic effect on the normal Vero cells (mean IC50s of 2.74, 3.50, 3.34 and 85.29 μM, respectively) [1].
UNSPSC
12352005
Target
CDK; PI3K
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C1/C(S/C(N1C2=CC=CC=C2)=N\CCNS(=O)(C3=CC=CC=C3)=O)=C\C4=CC=C(C=C4)Cl
Molecular Formula
C24H20ClN3O3S2
Molecular Weight
498.02
References & Citations
[1]Mohamed AR, et al. Integrated structure- and ligand-based design, synthesis, and biological evaluation of potent thiazole-based multi-kinase PI3Kα and CDK2/8 inhibitors as anticancer agents. Eur J Med Chem. 2025 Oct 15;296:117902.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK8; PI3Kα

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