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HDAC6-IN-58

CAT: 0804-HY-176064Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176064Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC6-IN-58 (compound 24c) is a selective HDAC6 inhibitor with IC50 values of 9.5 nM and 7374.5 nM for HDAC6 and HDAC1, respectively. HDAC6-IN-58 increases tubulin acetylation, exerts antiproliferative effects, and induces autophagy[1].
UNSPSC
12352005
Target
Autophagy; HDAC
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=CC(F)=C(C(F)=C1)CN2CN(C3(C2=O)CCN(CC4=CC=CC=C4)CC3)C5=CC=CC=C5)NO
Molecular Formula
C28H28F2N4O3
Molecular Weight
506.54
References & Citations
[1]Barone S, et al. Challenging triple negative breast cancer through HDAC6 selective inhibition: Novel cap-group identification, structure-activity relationships, computational and biological studies. Eur J Med Chem. 2025 Apr 18;292:117634.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6

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