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S1P1 agonist 7

CAT: 0804-HY-175984Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175984Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
S1P1 agonist 7 is a potent, orally active, and β-arrestin-biased S1P1 agonist (EC50 (G‑protein) = 12.7 nM and EC50 (β‑arrestin) = 3.23 nM) . S1P1 agonist 7 demonstrates potent immunomodulatory activity and a favorable safety profile. S1P1 agonist 7 exhibits excellent metabolic stability, minimal to moderate CYP inhibition, and S1P3-sparing selectivity. S1P1 agonist 7 shows pharmacokinetics, effectively reduces circulating lymphocytes, and significantly alleviates disease severity in experimental autoimmune encephalomyelitis (EAE) mouse models under both prophylactic and therapeutic regimens. S1P1 agonist 7 can be used for multiple sclerosis (MS) research[1].
UNSPSC
12352005
Target
LPL Receptor
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(O)CCC(N1C=CC2=C1C=CC(OCC3=CC=C(OC(C)C)C(C#N)=C3)=C2)=O
Molecular Formula
C23H22N2O5
Molecular Weight
406.43
References & Citations
[1]Lee CY, et al. Discovery of Novel β-Arrestin Biased Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis. J Med Chem. 2025 Sep 11;68 (17) :18289-18313.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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