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S1P1 agonist 7

CAT: 0013-GTR19273197-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273197-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
S1P1 agonist 7 is a potent and orally active β-arrestin-biased S1P1 agonist [EC50 (G-protein) = 12.7 nM, EC50 (β-arrestin) = 3.23 nM], exhibiting strong immunomodulatory activity and favorable safety. It has excellent metabolic stability, shows weak to moderate CYP inhibition, and demonstrates high selectivity without affecting the S1P3 receptor. In a mouse model of experimental autoimmune encephalomyelitis, S1P1 agonist 7 shows favorable pharmacokinetic properties, effectively reduces circulating lymphocyte counts, and significantly alleviates disease severity. This compound is applicable for research in multiple sclerosis.
Storage Conditions
-20°C
Notes
For research use only.

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