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HRZ-01-082-5

CAT: 0804-HY-175875Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175875Size:1 Each
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Description
HRZ-01-082-5 is an analog of Glutarimide. HRZ-01-082-5 is a dual-functional molecular glue degrader of SALL4 and OSR1 with a DC50 4.8 nM for OSR1. HRZ-01-082-5 significantly induced SALL4 and OSR1 degradation through CRBN. HRZ-01-082-5 can be used for heart and urogenital development, as well as cancers research[1].
CAS Number
3090685-19-8
UNSPSC
12352005
Target
Drug Derivative; Molecular Glues; Zinc Finger Protein
Related Pathways
Cell Cycle/DNA Damage; Others; PROTAC
Field of Research
Cancer; Cardiovascular Disease
Smiles
O=C1NC(C(CC1)N2C(C3=CC=C(C4=C(NC56CC7CC(C6)CC(C5)C7)N8N=CSC8=N4)C=C3C2=O)=O)=O
Molecular Formula
C27H26N6O4S
Molecular Weight
530.60
References & Citations
[1]Słabicki M, et al. Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation. Mol Cell. 2025 Aug 21;85 (16) :3184-3201.e14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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