Dual AChE-MAO B-IN-4

Dual AChE-MAO B-IN-4

• UNSPSC Description: Dual AChE-MAO B-IN-4 (compound 7) is a dual AChE/MAO-B inhibitor, with IC50 values ​​of 261 nM and 15 nM, respectively. Dual AChE-MAO B-IN-4 protects against oxidative damage induced by H2O2 and 6-OHDA in SH-SY5Y cells. Dual AChE-MAO B-IN-4 can penetrate the central nervous system in a cell model that mimics the blood-brain barrier. Dual AChE-MAO B-IN-4 can be used in the study of neurological diseases such as Alzheimer's disease (AD)[1].
• Target Antigen: Cholinesterase (ChE); Monoamine Oxidase
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/dual-ache-mao-b-in-4.html
• Smiles: O=C1C=C(CO)C2=C(O1)C=C(OCC3=CC=C(CN(C)CC4=CSC=C4)C=C3)C=C2
• Molecular Weight: 421.51
• References & Citations: [1]La Spada G,et al. Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization. Eur J Med Chem. 2024 May 19;274:116511.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported