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TRPM8 antagonist 4

CAT: 0804-HY-174825Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174825Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRPM8 antagonist 4 is a CB2R partial agonist (EC50=54.2 nM, Ki=3.2 μM) and TRPM8 antagonists (IC50=42.3 nM) with high functional selectivity and good physicochemical properties. TRPM8 antagonist 4 has significant anti-inflammatory and analgesic effects and good safety, reduces the mRNA expression of TNF-α, IL-6, and IL-1β[1].
UNSPSC
12352005
Target
Cannabinoid Receptor; Interleukin Related; TNF Receptor; TRP Channel
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(N)C1=C(O)C=C(OC/C=C(C)/CC/C=C(C)/C)C=C1C2CC2
Molecular Formula
C20H27NO3
Molecular Weight
329.43
References & Citations
[1]Yang W, et al. Identification of Cannabigerol-Derived Dual CB2 Receptor Agonists and TRPM8 Antagonists with Anti-Inflammatory and Analgesic Activities. J Med Chem. 2025 Jul 10;68 (13) :13335-13357.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB2; IL-1; IL-6; TNFRSF5/CD40; TRPM8

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