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NGI-189

CAT: 0013-GTR19272855-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19272855-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NGI-189 is a selective OST-A inhibitor. Its main mechanism is to inhibit the activity of the STT3A catalytic subunit in the OST complex, thereby reducing the N-glycosylation level of target glycoproteins. It effectively blocks the conduction of oncogenic and bypass signaling pathways, significantly downregulates the phosphorylation levels of EGFR, AKT, p70S6K and S6RP proteins, and induces cell cycle arrest and apoptosis. In non-small cell lung cancer (NSCLC) xenograft models, NGI-189 significantly inhibits tumor growth and induces tumor regression, making it a potential tool molecule for mechanism and efficacy research of EGFR-mutant non-small cell lung cancer.
CAS Number
2763063-26-7
Purity
99.47% (May vary between batches)
Smiles
O=C (NC1=NC=C (S1) CC) C2=CC (=CC=C2N (C) C3CCCC3) S (=O) (=O) N4CCOCC4
Molecular Formula
C22H30N4O4S2
Molecular Weight
478.63
Storage Conditions
-20°C
Notes
For research use only.

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