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ANO1-IN-5

CAT: 0804-HY-175669Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175669Size:1 Each
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Description
ANO1-IN-5 is an orally active ANO1 inhibitor with an IC50 of 4.57 μM. J ANO1-IN-5 demonstrates 118-, 642-, and 10000-fold selectivity over α1A-, α1B-, andα1D-AR, respectively. ANO1-IN-5 exhibits significant inhibitory effects on osteoclast differentiation and function. ANO1-IN-5 can used for the study of osteoporosis[1].
UNSPSC
12352100
Target
Chloride Channel
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Metabolic Disease
Smiles
O=S(C1=CC(CC(NC2CCN(C3=CC=CC=C3OCC)CC2)C)=CC=C1OC)(N)=O
Molecular Formula
C23H33N3O4S
Molecular Weight
447.59
References & Citations
[1]Tian C, et al. Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α1-Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents. J Med Chem. 2025 Aug 28;68 (16) :17705-17722.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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