ANO1-IN-4

ANO1-IN-4

• CAS Number: 2098490-06-1
• UNSPSC Description: ANO1-IN-4 (Compound 10bm) is a reversible inhibitor for calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1) with an IC50 of 0.030 µM. ANO1-IN-4 exhibits good metabolic stability in rat liver microsomes. ANO1-IN-4 inhibits spontaneous contraction in mouse isolated ileum[1].
• Target Antigen: Chloride Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/ano1-in-4.html
• Smiles: O=C(C1=C(NC(C(F)(Br)F)=O)SC2=C1CCCCC2)NC3=C(C)C=CC=C3
• Molecular Weight: 457.33
• References & Citations: [1]Truong EC, et al., Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A). J Med Chem. 2017 Jun 8;60(11):4626-4635.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported