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ANO1-IN-4

CAT: 0804-HY-153508-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153508-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ANO1-IN-4 (Compound 10bm) is a reversible inhibitor for calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1) with an IC50 of 0.030 µM. ANO1-IN-4 exhibits good metabolic stability in rat liver microsomes. ANO1-IN-4 inhibits spontaneous contraction in mouse isolated ileum[1].
CAS Number
2098490-06-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Chloride Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ano1-in-4.html
Purity
99.18
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=C(NC(C(F)(Br)F)=O)SC2=C1CCCCC2)NC3=C(C)C=CC=C3
Molecular Formula
C19H19BrF2N2O2S
Molecular Weight
457.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Truong EC, et al., Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A) . J Med Chem. 2017 Jun 8;60 (11) :4626-4635.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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