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KOR agonist 6

CAT: 0804-HY-175486Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175486Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KOR agonist 6 is a KOR agonist (Ki = 0.25 pM). KOR agonist 6 shows agonistic activity at MOR and DOR in CHO cells and inhibits Forskolin -stimulated cAMP accumulation. KOR agonist 6 stimulates KOR-mediated [35S]GTPγS binding and inhibits cAMP accumulation in KOR-expressing HEK293 cells with potent agonistic activity, while showing lower β-arrestin recruitment potency. KOR agonist 6 demonstrates anti-nociceptive efficacy in mice. KOR agonist 6 can be used for the study of analgesics with reduced central nervous system (CNS) side effects[1].
UNSPSC
12352005
Target
Opioid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(NC1=CC=C([C@H]2C[C@@]34CC[C@]2(OC)[C@H]5[C@]36C7=C(C(OC)=CC=C7CC4N(CC6)CC8CC8)O5)C=C1)C9=NN(C=C9)C
Molecular Formula
C35H40N4O4
Molecular Weight
580.72
References & Citations
[1]Kong L, et al. Structure-Activity Relationship of N-Cyclopropylmethyl-7α-[para- (arylcarboxamido) phenyl]-6,14-endoethano-tetrahydronorthebaines as Potent and Selective Kappa Opioid Receptor Agonists. J Med Chem. 2025 Aug 14;68 (15) :15889-15909.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
δ Opioid Receptor/DOR; κ Opioid Receptor/KOR; μ Opioid Receptor/MOR

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