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KOR agonist 4

CAT: 0804-HY-170973Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170973Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KOR agonist 4 (compound 39) is an agonist of Kappa Opioid Receptor. KOR agonist 4 is an activator of G-protein signaling. KOR agonist 4 binds with GTPγS with an EC50 of 14 nM and with an Emax of 83 %. KOR agonist 4 demonstrates moderate to high intrinsic clearance in human hepatocytes. KOR agonist 4 exhibits 60- and 810-fold selectivities versus the related mu (MOR) and delta (DOR) opioid receptors. KOR agonist 4 is potential for central nervous system (CNS) disorders research[1].
UNSPSC
12352005
Target
Opioid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Smiles
C1(C=C(CCN(CC2CC2)CCC3=CC=CC=C3)C=C4)=C4N=CN1
Molecular Formula
C21H25N3
Molecular Weight
319.44
References & Citations
[1]Schrader TO, et al. Novel tertiary diarylethylamines as functionally selective agonists of the kappa opioid receptor. Bioorg Med Chem Lett. 2025 Jan 24;120:130111.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
δ Opioid Receptor/DOR; κ Opioid Receptor/KOR; μ Opioid Receptor/MOR

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