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KOR agonist 1

CAT: 0804-HY-161539Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161539Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KOR agonist 1 (Compound 7a) is a selective agonist for opioid receptor, with EC50s of 3.4, 701.2 and 1649 nM, for KOR, MOR and DOR, respectively. KOR agonist 1 binds KOR, MOR and DOR, with Kis of 3.9, 1053 and 4196 nM, respectively. KOR agonist 1 exhibits antinociceptive effect in ICR mouse model (ED50 in hot plate test is 0.3 mg/kg, in abdominal constriction test is 0.2 mg/kg) [1].
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kor-agonist-1.html
Smiles
COC1=C(O2)C([C@]([C@@H]2[C@]3(OC)[C@@H](C4=CC=CC=C4NCC5=CC=CC=C5)C6)(CCN7CC8CC8)[C@@]6(CC3)C7C9)=C9C=C1
Molecular Formula
C37H42N2O3
Molecular Weight
562.74
References & Citations
[1]Li Z, et al., Discovery of an Ortho-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect. J Med Chem. 2024 May 9;67 (9) :7112-7129.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
δ Opioid Receptor/DOR; κ Opioid Receptor/KOR; μ Opioid Receptor/MOR

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