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P53 Activator 15

CAT: 0804-HY-175318SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175318SSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P53 Activator 15 is an orally active p53 Y220C activator. p53 Activator 15 enhances the DNA binding of p53 Y220C (SC50 = 0.58 nM) and significantly inhibits NUGC-3 cell proliferation. p53 Activator 15 effectively inhibits tumor growth in NUGC-3 xenograft mouse and rat models. p53 Activator 15 can be used to study gastric cancer[1].
CAS Number
3069395-29-2
UNSPSC
12352005
Target
MDM-2/p53
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NS(C)(=O)=O)C1=CC=C(NCC#CC2=C(N3C=CC=C(C3=C2)N[C@@H]4CCN(C[C@@H]4F)C)CC(F)(F)F)C(OC([2H])([2H])[2H])=N1
Molecular Formula
C27H27D3F4N6O4S
Molecular Weight
613.64
References & Citations
[1]Zhou G Q, et al. A class of N-sulfonylamide nitrogen-containing fused heterocyclic compounds targeting p53 mutation and their application. CN119350323A. 2025-06-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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