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P53 Activator 2

CAT: 0804-HY-146095Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146095Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P53 Activator 2 (compound 10ah) intercalats into DNA and results in significant DNA double-strand break.p53 Activator 2 increases the expression of p53, p-p53, CDK4, p21 to cause cell cycle arrest at G2/M phase.p53 Activator 2 induce apoptosis and significantly down-regulates the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1.p53 Activator 2 has anti-proliferation activity against MGC-803 cells, with an IC50 of 1.73 µM. p53 Activator 2 displays potent anticancer efficiency against MGC-803 xenograft tumors models[1].
CAS Number
2338764-89-7
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p53-activator-2.html
Solubility
10 mM in DMSO
Smiles
NCCCCNC1=NC(/C=C/C2=CC=C([N+]([O-])=O)C=C2)=NC3=C1C=CC=C3
Molecular Formula
C20H21N5O2
Molecular Weight
363.41
References & Citations
[1]Xin-Wei Wei , et al. 2-Styryl-4-aminoquinazoline derivatives as potent DNA-cleavage, p53-activation and in vivo effective anticancer agents. Eur J Med Chem. 2020 Jan 15;186:111851.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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