p53 Activator 2

• UNSPSC Description:

  p53 Activator 2 (compound 10ah) intercalats into DNA and results in significant DNA double-strand break.p53 Activator 2 increases the expression of p53, p-p53, CDK4, p21 to cause cell cycle arrest at G2/M phase.p53 Activator 2 induce apoptosis and significantly down-regulates the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1.p53 Activator 2 has anti-proliferation activity against MGC-803 cells, with an IC50 of 1.73 µM. p53 Activator 2 displays potent anticancer efficiency against MGC-803 xenograft tumors models[1].

• Target Antigen:

  Apoptosis; DNA/RNA Synthesis; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/p53-activator-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NCCCCNC1=NC(/C=C/C2=CC=C([N+]([O-])=O)C=C2)=NC3=C1C=CC=C3

• Molecular Weight:

  363.41

• References & Citations:

  [1]Xin-Wei Wei , et al. 2-Styryl-4-aminoquinazoline derivatives as potent DNA-cleavage, p53-activation and in vivo effective anticancer agents. Eur J Med Chem. 2020 Jan 15;186:111851.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2338764-89-7