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Hedgehog IN-11

CAT: 0013-GTR19264348-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264348-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HedgehogIN-11 is an orally active Hedgehog inhibitor. It reduces resistance to Temozolomide (TMZ) by downregulating O6-methylguanine-deoxyribonucleotides methyltransferase (MGMT) expression through the Hedgehog pathway. HedgehogIN-11 significantly inhibits the migration and invasion of TMZ-resistant glioblastoma cells and induces apoptosis. Computational modeling predicts good blood-brain barrier penetration for HedgehogIN-11. This compound is applicable for glioblastoma (GBM) research.
Field of Research
Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Storage Conditions
-20°C
Notes
For research use only.

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