ZN-c5

• Description :

  ZN-c5 is a selective and orally active estrogen receptor degrader. ZN-c5 exhibits high potency in the cellular assay (MCF-7, IC50 = 0.3 nM) and binds with high affinity to ERα and ERβ (IC50 = 0.4 nM and 0.8 nM, respectively) . ZN-c5 inhibits tumor growth in MCF-7 mouse xenograft model and WHIM20 xenograft model. ZN-c5 can be used for the study of breast cancer[1].

• UNSPSC :

  12352005

• Target :

  Estrogen Receptor/ERR

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  FC1=CC(/C=C/C(O)=O)=CC(F)=C1[C@H]2N([C@@H](CC3=C2NC4=CC=CC=C43)C)C56CC(C6)C5

• Molecular Formula :

  C26H24F2N2O2

• Molecular Weight :

  434.48

• References & Citations :

  [1]Hegde SG, et al. Discovery of ZN-c5, an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) with Improved Pharmacokinetics. J Med Chem. 2025 Jul 24;68 (14) :14740-14755.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2136606-87-4]