C5 Lenalidomide

• Description :

  C5 Lenalidomide (Lenalidomide 5'-amine) (Compound 8a) is a thalidomide analog and is a potent inhibitor of TNF-α production (IC50 = 100 μM in LPS stimulated human PBMC and IC50 = 480 nM in whole blood) [1].

• CAS Number :

  [191732-70-4]

• Product Name Alternative :

  Lenalidomide 5'-amine

• UNSPSC :

  12352005

• Hazard Statement :

  H361, H373

• Target :

  TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/c5-lenalidomide.html

• Purity :

  99.62

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(C(N(CC1=C2C=CC(N)=C1)C2=O)CC3)NC3=O

• Molecular Formula :

  C13H13N3O3

• Molecular Weight :

  259.26

• Precautions :

  H361, H373

• References & Citations :

  [1]G W Muller, et al. Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production. Bioorg Med Chem Lett. 1999 Jun 7;9 (11) :1625-30.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported