Zn (BQTC)

• Description :

  Zn (BQTC) is a highly potent mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) inhibitor. Zn (BQTC) causes severe damage to the mtDNA and nDNA, sequentially disruptes mitochondrial and nuclear functions. Zn (BQTC) promotes the DNA damage-induced apoptotic signaling pathway. Zn (BQTC) has selectively antiproliferative activity against A549R cells. Zn (BQTC) can be used for researching anticancer[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/zn-bqtc.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([N]12[Zn+2]([NH]3CC2)([NH]4CC3)[NH](CC4)CC1)CCCCCCOC5=C(OC6=CC=CC=C76)C7=NC8=CC=CC=C58.[Cl-].[Cl-]

• Molecular Formula :

  C30H39Cl2N5O3Zn

• Molecular Weight :

  653.95

• References & Citations :

  [1]Wang ZF, et al. Novel bifluorescent Zn (II) -cryptolepine-cyclen complexes trigger apoptosis induced by nuclear and mitochondrial DNA damage in cisplatin-resistant lung tumor cells [published online ahead of print, 2022 Apr 30]. Eur J Med Chem. 2022;238:114418.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2785342-54-1]