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Zn (BQTC)

CAT: 0804-HY-146287Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146287Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zn (BQTC) is a highly potent mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) inhibitor. Zn (BQTC) causes severe damage to the mtDNA and nDNA, sequentially disruptes mitochondrial and nuclear functions. Zn (BQTC) promotes the DNA damage-induced apoptotic signaling pathway. Zn (BQTC) has selectively antiproliferative activity against A549R cells. Zn (BQTC) can be used for researching anticancer[1].
CAS Number
2785342-54-1
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zn-bqtc.html
Solubility
10 mM in DMSO
Smiles
O=C([N]12[Zn+2]([NH]3CC2)([NH]4CC3)[NH](CC4)CC1)CCCCCCOC5=C(OC6=CC=CC=C76)C7=NC8=CC=CC=C58.[Cl-].[Cl-]
Molecular Formula
C30H39Cl2N5O3Zn
Molecular Weight
653.95
References & Citations
[1]Wang ZF, et al. Novel bifluorescent Zn (II) -cryptolepine-cyclen complexes trigger apoptosis induced by nuclear and mitochondrial DNA damage in cisplatin-resistant lung tumor cells [published online ahead of print, 2022 Apr 30]. Eur J Med Chem. 2022;238:114418.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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