HCA-IN-1

• Description:

  HCA-IN-1 (Compound 5u) is an hCA inhibitor with Ki values of 159.2, 4.8, 15.5, and 2 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. hCA-IN-1 exhibits broad-spectrum anticancer activity against melanoma, breast, and colon cancer cells. ADME predictions indicate that hCA-IN-1 has good solubility and oral bioavailability. hCA-IN-1 can be used in tumor research[1].

• UNSPSC:

  12352005

• Target:

  Carbonic Anhydrase

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Smiles:

  O=C(C(SC(SCC(NC1=CC=C(S(=O)(N)=O)C=C1)=O)=N2)=C2C)/C=C/C3=NC=CC=C3

• Molecular Formula:

  C20H18N4O4S3

• Molecular Weight:

  474.58

• References & Citations:

  [1]Elshamsy AM, et al. Design, Synthesis, and In Vitro Anticancer Evaluation of Thiazole-Based Chalcones Linked to Sulfanilamide as Tumor-Associated Carbonic Anhydrase IX and XII Inhibitors. J Med Chem. 2025 Jul 24;68 (14) :15151-15164.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CA II; CA I; CA IX; CA XII