NA-014

• Description:

  NA-014 (40) is a selective EAAT2 positive allosteric modulator (PAM), with an EC50 of 3 nM[1].

• UNSPSC:

  12352005

• Target:

  EAAT

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/na-014.html

• Purity:

  99.49

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(NCCC1=CC=C(F)C=C1)C(C2=CC=C(C#N)C=C2)N3CCN(C)CC3

• Molecular Formula:

  C22H25FN4O

• Molecular Weight:

  380.46

• References & Citations:

  [1]Andréia C K Fontana, et al. Synthesis and Structure-Activity Relationships for Glutamate Transporter Allosteric Modulators. J Med Chem. 2024 Apr 25;67 (8) :6119-6143.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported