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TNI-97

CAT: 0804-HY-175030Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175030Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TNI-97 is a selective and orally active HDAC6 inhibitor, with an IC50 of 0.2 nM. TNI-97 potently inhibited TNBC cell MDA-MB-453 growth and clonogenicity. TNI-97 induces PANoptosis including apoptosis, necroptosis and pyroptosis in MDA-MB-453 cells. TNI-97 shows antitumor activity in the mice carrying the MDA-MB-453 xenograft or carrying murine-derived TNBC cell allografts. TNI-97 can be used for the study of triple-negative breast cancer[1].
CAS Number
2790425-52-2
UNSPSC
12352005
Target
Apoptosis; HDAC; Necroptosis; Pyroptosis
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CN1N=NC2=C1C=CC(C3=NN(CC4=CC=C(C=C4)C(NO)=O)C(C(F)(F)F)=C3)=C2
Molecular Formula
C19H15F3N6O2
Molecular Weight
416.36
References & Citations
[1]Wang S, et al. Discovery of TNI-97 as a Highly Selective, Orally Bioavailable HDAC6 Inhibitor for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2025 Jul 24;68 (14) :14333-14356.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9

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