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KEA1-97

CAT: 0804-HY-114982-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114982-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM) . KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity[1].
CAS Number
2138882-71-8
Product Name Alternative
Desmethyldoxepin (hydrochloride), 4-Nitrophenylphosphorylcholine; 4-Nitrophenylphosphorylcholine; O-(4-Nitrophenylphosphoryl)choline
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kea1-97.html
Concentration
10mM
Purity
98.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=NC(Cl)=NC(NC2=CC=C(C=C2)C3=CC=C(C=C3)F)=N1
Molecular Formula
C15H9Cl2FN4
Molecular Weight
335.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Anderson KE, et al. Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity. ACS Chem Biol. 2017;12 (10) :2522-2528.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3

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