TNI-97

• Target:

  Apoptosis|||Necroptosis|||Pyroptosis|||HDAC

• Related Pathways:

  Immunology/Inflammation|||Apoptosis|||Chromatin/Epigenetic|||DNA Damage/DNA Repair

• Bioactivity:

  TNI-97 is a selective, orally active HDAC6 inhibitor with an IC50 value of 0.2 nM. It significantly suppresses the growth and colony-forming abilities of the triple-negative breast cancer (TNBC) cell line MDA-MB-453. In these cells, TNI-97 induces widespread cell death, including apoptosis, necroptosis, and pyroptosis. Additionally, TNI-97 demonstrates antitumor activity in mouse models bearing MDA-MB-453 xenograft tumors or syngeneic mouse-derived TNBC cell allograft tumors. TNI-97 is useful for researching triple-negative breast cancer.

• Smiles:

  O=C(NO)C1=CC=C(C=C1)CN2N=C(C=C2C(F)(F)F)C3=CC=C4C(N=NN4C)=C3

• Molecular Formula:

  C19H15F3N6O2

• Molecular Weight:

  416.36

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2790425-52-2