Apoptosis inducer 39

• Description :

  Apoptosis inducer 39 is an apoptosis inducer with IC50s of 4.53 and 15.42 μM against MDA-MB-231 and A549 cells. Apoptosis inducer 39 exerts in vitro anti-tumor activity by decreasing the expression of the anti-apoptotic protein Bcl-2 while increasing the expression of the pro-apoptotic protein Bax. Apoptosis inducer 39 can be used for the study of breast cancer and non-small lung cancer[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Bcl-2 Family

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=[N+](C1=CC2=NC(C(F)(F)F)=NC(NC3=CC=C(OC)C(Br)=C3)=C2C=C1)[O-]

• Molecular Formula :

  C16H10BrF3N4O3

• Molecular Weight :

  443.17

• References & Citations :

  [1]Yang M, et al. Synthesis of quinazoline derivatives and their in vitro inhibition activity against MDA-MB-231 cells and A549 cells. Bioorg Med Chem Lett. 2025 Nov 1;127:130308.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Bcl-2