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MMH-165-26

CAT: 0804-HY-174865Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174865Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MMH-165-26 is a ligand for RelA/p65. MMH-165-26 reduces the expression of RelA/p65 and has significant cytotoxicity in MEC-1 (LC50 = 0.37 μM) cells. MMH-165-26 can be used for synthesizing PROTACs such as JP-163-16.
UNSPSC
12352005
Target
Apoptosis; Ligands for Target Protein for PROTAC; NF-κB
Related Pathways
Apoptosis; NF-κB; PROTAC
Field of Research
Cancer
Smiles
NC1=CC=C(NC(CCCOC2=C(OC)C=C3C(N=C[C@@](CCC4)([H])N4C3=O)=C2)=O)C=C1
Molecular Formula
C23H26N4O4
Molecular Weight
422.48
References & Citations
[1]Jin P, et al. Design, synthesis and evaluation of pyrrolobenzodiazepine (PBD) -based PROTAC conjugates for the selective degradation of the NF-κB RelA/p65 subunit. RSC Med Chem. 2025 May 8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RelA/p65

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