TCH-165

• Description:

  TCH-165 is a small molecule modulator of proteasome assembly, which increases 20S levels and facilitates 20S-mediated protein degradation[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319

• Target:

  Proteasome

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tch-165.html

• Purity:

  98.42

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C ([C@]1 (C2=CC=CC=C2) N=C (C3=CC=C (OC) C=C3) N (CC4=CC=CC=C4) [C@@H]1C5=CC=C (NCC6=CC=CC=C6) C=C5) OCC

• Molecular Formula:

  C39H37N3O3

• Molecular Weight:

  595.73

• Precautions:

  H315, H319

• References & Citations:

  [1]Njomen E, et al. Small Molecule Modulation of Proteasome Assembly. Biochemistry. 2018 Jul 17;57 (28) :4214-4224.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1446350-60-2