VIR-165

• Description:

  VIR-165 is a modified form of virus inhibitory peptide (VIRIP) that binds the fusion peptide of the gp41 subunit and prevents its insertion into the target membrane. VIRIP inhibits a wide variety of human immunodeficiency virus type 1 (HIV-1) strains[1].

• UNSPSC:

  12352209

• Target:

  HIV

• Type:

  Peptides

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/vir-165.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1[C@@]2 ([H]) N (CCC2) C ([C@] (NC ([C@@H] (NC ([C@H] (CSSC[C@H] (NC ([C@@]3 ([H]) N1CCC3) =O) C (N[C@H] (C (N[C@@H] (C) C (N[C@H] (C (N[C@@H] (CC (N) =O) C (N[C@@H] (CCCCN) C (N4[C@@H] (CCC4) C (N[C@H] (C (N[C@@H] (C (C) C) C (N[C@H] (C (O) =O) CC5=CC=CC=C5) =O) =O) CC6=CC=CC=C6) =O) =O) =O) =O) CC7=CC=CC=C7) =O) =O) CC8=CC=CC=C8) =O) NC ([C@H]9N (CCC9) C ([C@H] ([C@@H] (C) CC) NC ([C@H] (C) NC ([C@H] (CCC (O) =O) NC ([C@@H] (N) CC (C) C) =O) =O) =O) =O) =O) =O) CO) =O) ([H]) [C@@H] (C) CC) =O

• Molecular Formula:

  C109H156N22O25S2

• Molecular Weight:

  2238.67

• References & Citations:

  [1]Münch J, et al. Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide. Cell. 2007 Apr 20;129 (2) :263-75.|[2]Eggink D, et al. HIV-1 Escape from a Peptidic Anchor Inhibitor through Stabilization of the Envelope Glycoprotein Spike. J Virol. 2016 Nov 14;90 (23) :10587-10599.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  943790-62-3