BER-5

CAT: 0804-HY-174452Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-174452Size:1 Each
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Description
BER-5 is a potent MrgX2 antagonist. BER-5 possess broad-spectrum antagonistic activity against a diverse range of MrgX2 agonists. BER-5 can inhibit Substance P (SP) (HY-P0201) -induced degranulation of LAD2 cells. BER-5 attenuates SP-induced allergic reactions in mice. BER-5 can be used for the study of allergic reactions[1].
CAS Number
[724709-67-5]
UNSPSC
12352005
Target
Calcium Channel; Interleukin Related; Mas-related G-protein-coupled Receptor (MRGPR)
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C1C=CC2=C(C3=C(OC=C3)C=C2O1)OCCCC4=CC=CC=C4
Molecular Formula
C20H16O4
Molecular Weight
320.34
References & Citations
[1]Odell LR, et al. The sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models. RSC Med Chem. 2023 Apr 26;14 (8) :1492-1511.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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