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BER-IN-1

CAT: 0013-GTR19272903-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19272903-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BER-IN-1 is a base excision repair (BER) inhibitor that specifically targets DNA apurinic/apyrimidinic (abasic) sites. It works by disrupting the BER pathway through β-elimination and β, δ-elimination cleavage at these sites, leading to DNA double-strand breaks (DSBs) . BER-IN-1 enhances the effects of the PARP inhibitor Olaparib in cancer cells with normal homologous recombination repair (HR) such as MDA-MB-231, HeLa, and SKOV3. When used in combination with Olaparib, BER-IN-1 can induce S-phase arrest and apoptosis. This compound is utilized in research on cancers, including breast, cervical, and ovarian cancers.
Storage Conditions
-20°C
Notes
For research use only.

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