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BER-IN-1

CAT: 0804-HY-175466Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175466Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BER-IN-1 is a base excision repair (BER) inhibtor, targeting DNA abasic sites. BER-IN-1 cleaves abasic sites via β- and β, δ-elimination mechanisms, disrupts the base excision repair (BER) pathway and leads to DNA double-strand breaks (DSBs). BER-IN-1 can enhance the effectiveness of the PARP inhibitor Olaparib in homologous recombination (HR) -proficient cancer cells (MDA-MB-231, HeLa, and SKOV3). BER-IN-1 induces an S-phase arrest and apoptosis companied with Olaparib (HY-10162). BER-IN-1 can be used for the research of cancer, such as breast, cervical and ovarian cancer[1].
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NC1=CC=C2N=C(N(C)CCCN3C)C3=NC2=C1
Molecular Formula
C13H17N5
Molecular Weight
243.31
References & Citations
[1]Bora A, et al. Disrupting the Base Excision Repair (BER) Pathway by Targeting the Abasic Site Enhances the Sensitivity of PARP Inhibitor in HR-Proficient Cancer Cells. ACS Chem Biol. 2025 Aug 15;20 (8) :1863-1874.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1

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