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AChE/BChE-IN-27

CAT: 0804-HY-174399Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174399Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE/BChE-IN-27 is a blood-brain barrier-permeable mixed inhibitor (Pe = 4.12) of AChE and BChE, with IC50 values of 3.72 μM and 9.65 μM, respectively. AChE/BChE-IN-27 has potent antioxidant activity with an IC50 value of 6.32 μM in the DPPH assay and also exhibits potent in vitro antioxidant activity. AChE/BChE-IN-27 exhibits metal chelating properties. AChE/BChE-IN-27 has neuroprotective potential against oxidative stress. AChE/BChE-IN-27 significantly reduces intracellular reactive oxygen species (ROS). In in vivo experiments, AChE/BChE-IN-27 effectively restored AChE and BChE levels, improved cognition, and can be used for Alzheimer's disease (AD).
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(CNC(/C=C/C1=CC(O)=C(C=C1)O)=O)NCCC2=CNC3=CC=CC=C23
Molecular Formula
C21H21N3O4
Molecular Weight
379.41
References & Citations
[1]Kumar S, et al.. Design, synthesis, and biological evaluation of caffeic acid-based novel multifunctional molecules for the management of Alzheimer's disease. Eur J Med Chem. 2025 Oct 15;296:117831.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

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