ELQ-453

• Description:

  ELQ-453 is an inhibitor targeting the Qo site of the Plasmodium falciparum cytochrome bc1 complex (CytB) with an IC50 value of 0.57 nM. ELQ-453 blocks the mitochondrial function of the parasite, and suppresses Plasmodium infection in mosquitoes. ELQ-453 is promising for research of malaria[1].

• UNSPSC:

  12352005

• Target:

  Cytochrome P450; Parasite

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Field of Research:

  Infection

• Smiles:

  FC1=C2C(N=C(C)C(CCCCCCC)=C2OCOC(OCC)=O)=CC(F)=C1

• Molecular Formula:

  C21H27F2NO4

• Molecular Weight:

  395.44

• References & Citations:

  [1]Probst AS, et al. In vivo screen of Plasmodium targets for mosquito-based malaria control. Nature. 2025 May 21.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported