ELQ-121

CAT: 0931-T210705-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T210705-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1228283-36-0

Target

Parasite

Related Pathways

Microbiology/Virology

Bioactivity

ELQ-121 is a potent inhibitor of the ubiquinol oxidation (QO) site in parasites. It exhibits an in vitro IC50 of 0.05 nM against both chloroquine-sensitive and multi-drug resistant Plasmodium falciparum. ELQ-121 also inhibits Toxoplasma gondii and Neospora caninum with an in vitro IC50 of less than 1 nM. It hinders the proliferation of Bacteroides fragilis tachyzoites with an IC50 of 0.49 nM and induces mitochondrial disruption. Furthermore, ELQ-121 can be formulated into a polyethylene glycol carbonate prodrug, which shows efficacy against P. yoelii in mice. ELQ-121 is applicable for antimalarial research.

Smiles

O=C1C=2C(F)=CC(F)=CC2NC(=C1CCCCCCC)C

Molecular Formula

C17H21F2NO

Molecular Weight

293.35

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
GTR19263217-01	ELQ-121
BA2101-10	ELQ-300
HY-163482	ELQ-596
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GTR19235406-01	ELQ-650
GTR19263473-01	ELQ-453
HY-171190	ELQ-316
A21234-50	ELQ-300 50mg
A21234-10	ELQ-300 10mg
A21234-5	ELQ-300 5mg

ELQ-121

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