USP7-IN-18

CAT: 0804-HY-174301Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-174301Size:1 Each
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Description
USP7-IN-18 is a naphthalene derivative. USP7-IN-18 is a selective USP7 inhibitor (IC50 : 130.9 nM), with no or very weak inhibition of the other 8 DUBs including USP47. USP7-IN-18 specifically binds to the catalytic domain of USP7, blocking its deubiquitinase activity. USP7-IN-18 causes degradation of the oncogenic proteins MDM2 and DNMT1, and also degrades the novel target PCLAF. USP7-IN-18 activates the p53-p21 pathway. USP7-IN-18 exerts anti-tumor effects in colon cancer animal models and reshapes the tumor immune microenvironment. USP7-IN-18 achieves both direct cytotoxic and immune-synergistic anti-tumor actions[1].
CAS Number
[3052223-40-9]
UNSPSC
12352005
Target
Deubiquitinase; DNA Methyltransferase; MDM-2/p53
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1(C2C(N(C(C21)=O)CC3=CC4=C(C(C5=CC(Cl)=C6C=CC=CC6=C5OC7CCNCC7)=CC=N4)S3)=O)C
Molecular Formula
C30H28ClN3O3S
Molecular Weight
546.08
References & Citations
[1]Xian Zhang, et al. Discovery of indane and naphthalene derivatives as USP7 inhibitors. Eur J Med Chem. 2025 May 29. 295:117824.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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