USP7-797

• Description:

  USP7-797 (USP7-IN-7) is an orally available, selective USP7 inhibitor (IC50=0.5 nmol/L) with antitumor activity. USP7-797 reduces the level of MDM2, thereby increasing the stability and activity of p53, leading to cell cycle arrest and apoptosis. USP7-797 has low nanomolar cytotoxicity against p53 mutant cancer cell lines, p53 wild-type hematological tumors, and neuroblastoma cell lines[1][2].

• Product Name Alternative:

  USP7-IN-7

• UNSPSC:

  12352005

• Target:

  Deubiquitinase; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/usp7-797.html

• Concentration:

  10mM

• Purity:

  99.09

• Solubility:

  DMSO : 75 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(N1CC2=CC3=NC=CC(C4=CC(Cl)=CC(C)=C4C[C@@H]5CNCCO5)=C3S2)C6C(C)(C)C6C1=O

• Molecular Formula:

  C27H28ClN3O3S

• Molecular Weight:

  510.05

• References & Citations:

  [1]Biannic, Berenger, et al. UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF. US20200095260. 2019.|[2]Ohol YM, et al. Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity In Vitro and In Vivo. Mol Cancer Ther. 2020 Oct;19 (10) :1970-1980.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  USP7

• CAS Number:

  [2413944-70-2]