USP7-IN-9

• Description:

  USP7-IN-9 is a highly potent ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 value of 40.8 nM. USP7-IN-9 can induce apoptosis and arrest cell progression at G0/G1 and S phases in RS4; 11 cells. USP7-IN-9 reduces the protein levels of oncoproteins MDM2 and DNMT1 and increases the protein levels of tumor suppressors p53 and p21[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Deubiquitinase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/usp7-in-9.html

• Purity:

  98.10

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC1 (CN (C=NC2=C (C3=CC=C (C[NH3+]) C=C3) N (C) N=C24) C4=O) CC[NH+] (CC5=CC=C (C (OC) =O) C=C5Cl) CC1.O=C ([O-]) C (F) (F) F.O=C ([O-]) C (F) (F) F

• Molecular Formula:

  C32H33ClF6N6O8

• Molecular Weight:

  779.08

• References & Citations:

  [1]Li M, Liu S, Chen H, et al. N-benzylpiperidinol derivatives as novel USP7 inhibitors: Structure-activity relationships and X-ray crystallographic studies. Eur J Med Chem. 2020;199:112279.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2444374-01-8