USP7-IN-9

• Target :

  Others|||DUB|||Apoptosis

• Related Pathways :

  DNA Damage/DNA Repair|||Ubiquitination|||Cell Cycle/Checkpoint|||Others|||Apoptosis

• Bioactivity :

  USP7-IN-9, a potent inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 40.8 nM, effectively induces apoptosis and arrests cell progression at the G0/G1 and S phases in RS4;11 cells. It decreases the protein levels of oncoproteins MDM2 and DNMT1 while enhancing the levels of tumor suppressors p53 and p21.

• Smiles :

  COC(C1=CC=C(C[NH+]2CCC(CC2)(O)CN(C=NC3=C4C5=CC=C(C[NH3+])C=C5)C(C3=NN4C)=O)C(Cl)=C1)=O.O=C([O-])C(F)(F)F.O=C([O-])C(F)(F)F

• Molecular Formula :

  C32H33ClF6N6O8

• Molecular Weight :

  779.08

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C