USP7-IN-2

USP7-IN-2

• CAS Number: 2196243-57-7
• UNSPSC Description: USP7-IN-2 (compound 4) is a non-competitive USP7 inhibitor with an IC50 of 6 nM. USP7-IN-2 causes degradation of MDM2, stabilization of p53 and induction of p21 in multiple cell lines, and can be utilized in cancer research[1].
• Target Antigen: Deubiquitinase; MDM-2/p53
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/usp7-in-2.html
• Smiles: O=C1C2=NN(C)C(C3=CC=C(CN)C=C3)=C2N=CN1CC4(O)CCN(C(C[C@H](C5=CC=CC=C5)C)=O)CC4
• Molecular Weight: 514.62
• References & Citations: [1]Gavory G, et al. Discovery and characterization of highly potent and selective allosteric USP7 inhibitors. Nat Chem Biol. 2018 Feb;14(2):118-125.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported