MNN-02-155

• Description :

  MNN-02-155 is a bivalent molecular glue with with dual binding to p300/CBP and BCL6. MNN-02-155 induces potent activation of the BCL6-target reporter gene and cell death. MNN-02-155 can be used for the study of diffuse large B cell lymphomas (DLBCLs) [1].

• UNSPSC :

  12352005

• Target :

  BCL6; Histone Acetyltransferase; Molecular Glues

• Related Pathways :

  Epigenetics; Immunology/Inflammation; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C(N1CC2=C(CC1)N(C3CCN(CC3)C(CCCCNC(C4CCN(CC4)C5=NC=C(C(NC6=CC(C=C(C(N7C)=O)OCC(NC)=O)=C7C(OC)=C6)=N5)Cl)=O)=O)N=C2N8C9=C(CCC8)C=C(C%10=CN(C)N=C%10)C(C(F)F)=C9)NC

• Molecular Formula :

  C56H68ClF2N15O7

• Molecular Weight :

  1136.69

• References & Citations :

  [1]Nix MN, et al. A Bivalent Molecular Glue Linking Lysine Acetyltransferases to Oncogene-induced Cell Death. bioRxiv [Preprint]. 2025 Mar 17:2025.03.14.643404.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3067681-22-2]