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NMDAR antagonist 5

CAT: 0804-HY-173398Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173398Size:1 Each
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Description
NMDAR antagonist 5 (Compound A17) is a multi-target antagonist against NMDAR and monoamine transporters (SERT、DAT and NET) . NMDAR antagonist 5 shows good NMDAR antagonistic potency (IC50 = 0.3 μM) and monoamine transporter activities (SERT IC50 = 1.1 μM、DAT IC50 = 0.7 μM、NET IC50 = 2.7 μM) . NMDAR antagonist 5 is highly safe and has low toxicity (hepatotoxicity and nephrotoxicity (IC50 > 100 μM) ; cardiotoxicity (IC50 = 24.5 μM) ) . NMDAR antagonist 5 has antidepressant effects and can be used in the study of depression[1].
CAS Number
3038464-68-2
UNSPSC
12352005
Target
Dopamine Transporter; iGluR; Monoamine Transporter; Serotonin Transporter
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
C1([C@]2(N3CCCC3)CC(C=NN4)=C4CC2)=CC=CC=C1
Molecular Formula
C17H21N3
Molecular Weight
267.37
References & Citations
[1]Zheng F, et al. Heterocycle-fused phenylcyclohexylamines as novel multi-target antagonists of N-methyl-D-aspartate (NMDA) receptor and monoamine transporter for treating depression. Eur J Med Chem. 2025 Jul 5;291:117538.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor

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