TYK2 ligand 2

• Description :

  TYK2 ligand 2 is a TYK2 ligand for TYD-68 (HY-173357) . TYD-68 is a highly efficient and selective CRBN-recruited TYK2 PROTAC degrader with a DC50 value of 0.42 nM. TYD-68 can be used in the study of psoriasis[1].

• CAS Number :

  [2924460-80-8]

• UNSPSC :

  12352005

• Target :

  JAK

• Related Pathways :

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research :

  Inflammation/Immunology

• Smiles :

  COC1=C(C=CC=C1C2=NC=C(C=N2)F)NC3=CC(NC4=CC=C(C=N4)C(O)=O)=NC=C3C(NC)=O

• Molecular Formula :

  C24H20FN7O4

• Molecular Weight :

  489.46

• References & Citations :

  [1]Xiong S, et al. Discovery of a Highly Potent and Selective Tyrosine Kinase 2 (TYK2) Degrader with In Vivo Therapeutic Efficacy in a Murine Psoriasis Model. J Med Chem. 2025 Apr 10;68 (7) :7560-7578.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Tyk2